Sorry to go off on a mild tangent, but here goes ... don't know about the Blob, but Spider-Man often took on huge guys much stronger than he was (Rhino, Ox, Juggernaut) by using the most likely little man vs big man strategy, what I call the Bugs Bunny defense : using speed, agility and cleverness to dodge around and tire out the bigger man until he gets mad enough to make a fatal mistake, then capitalize on it. And even when he beat the Juggernaut, it took a lucky break and he took an horrific beating doing it.